Role of CD26-adenosine deaminase interaction in T cell-mediated immunity
نویسنده
چکیده
RESUMEN CD26 es una ectopeptidasa de 110 kDa anclada en la superficie celular con una actividad dipeptidil peptidasa IV (DPPIV) intrínseca, la cual une a la adenosina desaminasa (ADA) sobre la superficie de células T. ADA es un enzima del metabolismo de las purinas la cual ha sido el objeto de interés considerable, principalmente porque la deficiencia congénita de ésta causa inmunodeficiencia severa combinada (SCID). Esta revisión está enfocada en la demostración de que la interacción CD26-ADA tiene un papel clave en la inmunidad mediada por células T. Los papeles enzimáticos tanto como extra-enzimáticos tanto de ADA como de CD26 son discutidos en el contexto inmunológico. Además, la estructura del complejo CD26-ADA, las vías de transducción de señal activadas por la interacción co-estimuladora ADA-CD26 y el patrón de citocinas inducido durante el establecimiento de la inmunosinapsis son analizados. En este contexto, serán discutidas las implicaciones que conlleva la interferencia en la interacción CD26-ADA y en sus actividades catalíticas en la fisiopatología del SIDA.
منابع مشابه
Regulation of epithelial and lymphocyte cell adhesion by adenosine deaminase-CD26 interaction.
The extra-enzymic function of cell-surface adenosine deaminase (ADA), an enzyme mainly localized in the cytosol but also found on the cell surface of monocytes, B cells and T cells, has lately been the subject of numerous studies. Cell-surface ADA is able to transduce co-stimulatory signals in T cells via its interaction with CD26, an integral membrane protein that acts as ADA-binding protein. ...
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